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Nevertheless, a considerable proportion of patients do not respond sufficiently to NSAHs.

According to Humphreys and Hunter up to 40% of patients with CU may not achieve good control with antihistaminic therapy [].

Please see package insert for additional information and possible updates.

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.

[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.

Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

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Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.

Inducible urticarias include all forms of physical urticarias (cold-induced, heat-induced, solar, and pressure urticaria).

According to the International Guidelines for the management of urticaria and angioedema non-sedating, second generation antihistamines (NSAHs) are recommended for the treatment of CU [].

Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.

Desloratadine inhibited histamine release from human mast cells in vitro.

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